A potential role for insulin resistance in experimental pulmonary hypertension.

@article{West2013APR,
  title={A potential role for insulin resistance in experimental pulmonary hypertension.},
  author={James D. West and Kevin D. Niswender and Jennifer A. Johnson and Meredith E. Pugh and Linda A. Gleaves and Joshua Patrick Fessel and Anna R Hemnes},
  journal={The European respiratory journal},
  year={2013},
  volume={41 4},
  pages={861-71}
}
Patients with pulmonary arterial hypertension have increased prevalence of insulin resistance. We aimed to determine whether metabolic defects are associated with bone morphogenic protein receptor type 2 (Bmpr2) mutations in mice, and whether these may contribute to pulmonary vascular disease development. Metabolic phenotyping was performed on transgenic mice with inducible expression of Bmpr2 mutation, R899X. Phenotypic penetrance in Bmpr2(R899X) was assessed in a high-fat diet model of… CONTINUE READING
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