A potential role for immune complex pathogenesis in drusen formation.

@article{Johnson2000APR,
  title={A potential role for immune complex pathogenesis in drusen formation.},
  author={Lincoln V. Johnson and Shoichi Ozaki and Michelle K Staples and Page A. Erickson and Don H. Anderson},
  journal={Experimental eye research},
  year={2000},
  volume={70 4},
  pages={441-9}
}
Drusen are abnormal extracellular deposits that accumulate between the retinal pigmented epithelium and Bruch's membrane and are commonly associated with age-related macular degeneration. Our recent work has identified a number of plasma proteins as molecular components of drusen. Of interest is the fact that many of these drusen-associated molecules are acute phase reactant proteins and some have established roles in mediating immune responsiveness. As immune and inflammatory responses appear… CONTINUE READING