A potential role for fructose-2,6-bisphosphate in the stimulation of hepatic glucokinase gene expression.

@article{Wu2004APR,
  title={A potential role for fructose-2,6-bisphosphate in the stimulation of hepatic glucokinase gene expression.},
  author={Chaodong Wu and David A Okar and Angela K Stoeckman and L Peng and Amy H. Herrera and Julio E Herrera and Howard C. Towle and Alex J. Lange},
  journal={Endocrinology},
  year={2004},
  volume={145 2},
  pages={650-8}
}
The effects of fructose-2,6-bisphosphate (F-2,6-P(2)) on hepatic glucokinase (GK) and glucose-6-phosphatase (G-6-Pase) gene expression were investigated in streptozotocin-treated mice, which exhibited undetectable levels of insulin. Hepatic F-2,6-P(2) levels were manipulated by adenovirus-mediated overexpression of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. Streptozotocin treatment alone or with infusion of control adenovirus leads to a dramatic decrease in hepatic F-2,6-P(2) content… CONTINUE READING