A potential role for endothelin-1 in human placental growth: interactions with the insulin-like growth factor family of peptides.

Abstract

Endothelin-1 (Et-1) stimulated DNA synthesis in placental fibroblasts in a dose-dependent manner, as measured by [3H]thymidine incorporation (ED50, 0.2-0.3 ng/mL). Insulin-like growth factor-I (IGF-I) interacted synergistically with Et-1 to potentiate the stimulation of DNA synthesis. Additionally, Et-1 stimulated the turnover of phosphoinositides in a time… (More)

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