A potential role for ICP, a Leishmanial inhibitor of cysteine peptidases, in the interaction between host and parasite.

@article{Besteiro2004APR,
  title={A potential role for ICP, a Leishmanial inhibitor of cysteine peptidases, in the interaction between host and parasite.},
  author={S{\'e}bastien Besteiro and Graham H. Coombs and Jeremy C Mottram},
  journal={Molecular microbiology},
  year={2004},
  volume={54 5},
  pages={1224-36}
}
The biological role of a natural inhibitor of cysteine peptidases (designated ICP) of Leishmania has been investigated by genetic manipulation of the parasite. Null mutants grew normally in vitro, were as infective to macrophages in vitro as wild-type parasites, but had reduced infectivity to mice. Mutants re-expressing ICP from a single gene gave partial restoration of virulence in vivo, whereas mutants overexpressing ICP secreted the inhibitor and showed markedly reduced virulence in mice… CONTINUE READING
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