A potential dichotomous role of ATF3, an adaptive-response gene, in cancer development

Abstract

Activating transcription factor 3 (ATF3) is a member of the ATF/cyclic AMP response element-binding family of transcription factors. We present evidence that ATF3 has a dichotomous role in cancer development. By both gain- and loss-of-function approaches, we found that ATF3 enhances apoptosis in the untransformed MCF10A mammary epithelial cells, but… (More)
DOI: 10.1038/sj.onc.1210861

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