A potent antiangiogenic factor, endostatin prevents the development of asthma in a murine model.

@article{Suzaki2005APA,
  title={A potent antiangiogenic factor, endostatin prevents the development of asthma in a murine model.},
  author={Yasue Suzaki and Kaoru Hamada and Masayuki Sho and Toshihiro Ito and Kenichi Miyamoto and Satoru Akashi and Hisanori Kashizuka and Naoya Ikeda and Yoshiyuki Nakajima and Michiko Iwase and Ikuo Homma and Lester Kobzik and Hiroshi Kimura},
  journal={The Journal of allergy and clinical immunology},
  year={2005},
  volume={116 6},
  pages={1220-7}
}
BACKGROUND Clinical studies suggest a role for angiogenesis in the development and persistence of chronic asthma, but whether angiogenic mediators contribute to acute asthma has not been fully studied. OBJECTIVE The aim of this study was to investigate a role of vascular endothelial growth factor (VEGF), a major angiogenic and proinflammatory mediator, in allergen-induced acute asthma and to determine whether endostatin/Fc, a potent antiangiogenic factor can attenuate allergic airway… CONTINUE READING
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