A potent and specific morpholino antisense inhibitor of hepatitis C translation in mice

  title={A potent and specific morpholino antisense inhibitor of hepatitis C translation in mice},
  author={A. McCaffrey and L. Meuse and Mobin Karimi and C. Contag and M. Kay},
  • A. McCaffrey, L. Meuse, +2 authors M. Kay
  • Published 2003
  • Medicine, Biology
  • Hepatology
  • Hepatitis C virus (HCV) is an RNA virus infecting one in every 40 people worldwide. Current treatments are ineffective and HCV is the leading cause of liver failure leading to transplantation in the United States and Europe. Translational control of HCV is a prime therapeutic target. We assessed the inhibitory potential of morpholino phosphoramidate antisense oligonucleotides (morpholinos) on HCV translation by codelivering them with reporter plasmids expressing firefly luciferase under the… CONTINUE READING
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