A potent and specific morpholino antisense inhibitor of hepatitis C translation in mice

@article{McCaffrey2003APA,
  title={A potent and specific morpholino antisense inhibitor of hepatitis C translation in mice},
  author={A. McCaffrey and L. Meuse and Mobin Karimi and C. Contag and M. Kay},
  journal={Hepatology},
  year={2003},
  volume={38}
}
  • A. McCaffrey, L. Meuse, +2 authors M. Kay
  • Published 2003
  • Medicine, Biology
  • Hepatology
  • Hepatitis C virus (HCV) is an RNA virus infecting one in every 40 people worldwide. Current treatments are ineffective and HCV is the leading cause of liver failure leading to transplantation in the United States and Europe. Translational control of HCV is a prime therapeutic target. We assessed the inhibitory potential of morpholino phosphoramidate antisense oligonucleotides (morpholinos) on HCV translation by codelivering them with reporter plasmids expressing firefly luciferase under the… CONTINUE READING
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    References

    SHOWING 1-10 OF 31 REFERENCES
    Determinants of hepatitis C translational initiation in vitro, in cultured cells and mice.
    • 98
    • PDF
    Targeted inhibition of hepatitis C virus-directed gene expression in human hepatoma cell lines.
    • 38
    Antisense Oligonucleotide Inhibition of Hepatitis C Virus (HCV) Gene Expression in Livers of Mice Infected with an HCV-Vaccinia Virus Recombinant
    • 71
    • PDF
    Enhanced antiviral effect in cell culture of type 1 interferon and ribozymes targeting HCV RNA
    • 33