A potent and selective small molecule inhibitor of sirtuin 1 promotes differentiation of pluripotent P19 cells into functional neurons

@inproceedings{Kim2016APA,
  title={A potent and selective small molecule inhibitor of sirtuin 1 promotes differentiation of pluripotent P19 cells into functional neurons},
  author={Beom Seok Kim and Chang-Hee Lee and Gyeong-Eon Chang and Eunji Cheong and Injae Shin},
  booktitle={Scientific reports},
  year={2016}
}
Sirtuin 1 (SIRT1) is known to suppress differentiation of pluripotent/multipotent cells and neural progenitor cells into neurons by blocking activation of transcription factors critical for neurogenesis. EX-527 is a highly selective and potent inhibitor against SIRT1 and has been used as a chemical probe that modulates SIRT1-associated biological processes… CONTINUE READING