A potent 2′-O-methylated RNA-based microRNA inhibitor with unique secondary structures

@inproceedings{Haraguchi2012AP2,
  title={A potent 2′-O-methylated RNA-based microRNA inhibitor with unique secondary structures},
  author={Takeshi Haraguchi and Haruo Nakano and Takanobu Tagawa and Tokimitsu Ohki and Yoshihito Ueno and Tetsuo Yoshida and Hideo Iba},
  booktitle={Nucleic acids research},
  year={2012}
}
MicroRNAs (miRNAs) are involved in various biological processes and human diseases. The development of strong low-molecular weight inhibitors of specific miRNAs is thus expected to be useful in providing tools for basic research or in generating promising new therapeutic drugs. We have previously described the development of 'Tough Decoy (TuD) RNA' molecules, which achieve the long-term suppression of specific miRNA activity in mammalian cells when expressed from a lentivirus vector. In our… CONTINUE READING
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