A posttranscriptional role for the yeast Paf1-RNA polymerase II complex is revealed by identification of primary targets.

@article{Penheiter2005APR,
  title={A posttranscriptional role for the yeast Paf1-RNA polymerase II complex is revealed by identification of primary targets.},
  author={Kristi L Penheiter and Taylor M Washburn and Stephanie E Porter and Matthew G Hoffman and Judith A. Jaehning},
  journal={Molecular cell},
  year={2005},
  volume={20 2},
  pages={213-23}
}
The yeast Paf1 complex (Paf1C: Paf1, Cdc73, Ctr9, Rtf1, and Leo1) is associated with RNA Polymerase II (Pol II) at promoters and coding regions of transcriptionally active genes, but transcript abundance for only a small subset of genes is altered by loss of Paf1. By using conditional and null alleles of PAF1 and microarrays, we determined the identity of… CONTINUE READING