A post-antibiotic era looms: can plant natural product research fill the void?

  title={A post-antibiotic era looms: can plant natural product research fill the void?},
  author={C. Kenny and A. Furey and B. Lucey},
  journal={British Journal of Biomedical Science},
  pages={191 - 200}
Abstract Antimicrobial resistance is increasing among certain pathogenic bacteria to the extent that treatment efficacy is no longer always assured. According to the CDC, as few as six new antibiotics have been released for use over the past 30 years. Resistance has already been observed to each of these. Eleven plant natural products have been approved for therapeutic use during the same period – none of them being antimicrobial agents. We have learned through experience that some… Expand
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Plant Secondary Metabolites in the Battle of Drugs and Drug-Resistant Bacteria: New Heroes or Worse Clones of Antibiotics?
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British Journal of Biomedical Science in 2016. What have we learned?
  • A. Blann
  • Medicine, Biology
  • British journal of biomedical science
  • 2017
The present report will summarise key aspects of these publications that are of greatest relevance to laboratory scientists. Expand


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Recent Trends and Methods in Antimicrobial Drug Discovery from Plant Sources
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Screening methods to determine antibacterial activity of natural products
Evaluating technical variants used in screening methods to determine antibacterial activity of natural products found bioautographic and diffusion techniques were found to have similar sensitivity; however the latter technique provided more suitable conditions for the microbial growth. Expand
Medicinal plants and antimicrobial activity.
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Anti-infective potential of natural products: how to develop a stronger in vitro 'proof-of-concept'.
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Optimal methods for evaluating antimicrobial activities from plant extracts.
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Screening methods for natural products with antimicrobial activity: a review of the literature.
All the various techniques are reviewed here and, in order to unify the different criteria and parameters, standard methods to study the antimicrobial activity of medicinal plants are proposed. Expand
Critical analysis of current methods for assessing the in vitro antioxidant and antibacterial activity of plant extracts.
This review primarily aims to give a better understanding in the selection of in vitro assays, with emphasis placed on some common assays such as the total phenolic content assay, free radical scavenging activity, disc-diffusion and broth microdilution. Expand