A post-CD4-binding step involving interaction of the V3 region of viral gp120 with host cell surface glycosphingolipids is common to entry and infection by diverse HIV-1 strains.

@article{Nehete2002APS,
  title={A post-CD4-binding step involving interaction of the V3 region of viral gp120 with host cell surface glycosphingolipids is common to entry and infection by diverse HIV-1 strains.},
  author={Pramod N Nehete and Eric Michael Vela and Mohammad M. Hossain and Asis K Sarkar and Nouara Yahi and Jacques Fantini and K Jagannadha Sastry},
  journal={Antiviral research},
  year={2002},
  volume={56 3},
  pages={233-51}
}
The V3-loop region in the envelope protein gp120 of HIV is critical for viral infection, but its interaction with the target cells is not clear. Using synthetic peptides, representing linear V3 sequences as reagents, we obtained evidence to show inhibition of infection by both T-cell- and macrophage-tropic strains of human immunodeficiency virus type 1 (HIV-1) (X4 and R5, respectively), without interfering with gp120-CD4 interaction, by the V3 peptides through binding to host cell membrane… CONTINUE READING
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