A possible unifying principle for mechanosensation

@article{Kung2005APU,
  title={A possible unifying principle for mechanosensation},
  author={C. Kung},
  journal={Nature},
  year={2005},
  volume={436},
  pages={647-654}
}
  • C. Kung
  • Published 2005
  • Medicine, Biology
  • Nature
  • Of Aristotle's five senses, we know that sight, smell and much of taste are initiated by ligands binding to G-protein-coupled receptors; however, the mechanical sensations of touch and hearing remain without a clear understanding of their molecular basis. Recently, the relevant force-transducing molecules—the mechanosensitive ion channels—have been identified. Such channel proteins purified from bacteria sense forces from the lipid bilayer in the absence of other proteins. Recent evidence has… CONTINUE READING
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