A possible tumor suppressor gene for parathyroid adenomas.

Abstract

Many short sequence repeat polymorphisms (SSRP) have been reported recently. There have been few reports of loss of heterozygosity (LOH) in tumors, employing these SSRP markers. The author examined loss of heterozygosity in 19 MEN-1 tumors and 43 sporadic parathyroid adenomas. All 19 (100%) MEN-1 tumors showed allelic loss on chromosome 11q. 15 out of 43… (More)

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