A possible role of the ATP-sensitive potassium ion channel in determining the duration of spike-bursts in mouse pancreatic beta-cells.

@article{Ding1996APR,
  title={A possible role of the ATP-sensitive potassium ion channel in determining the duration of spike-bursts in mouse pancreatic beta-cells.},
  author={W. G. Ding and Leshui He and Mariko Omatsu-Kanbe and Hiroshi Kitasato},
  journal={Biochimica et biophysica acta},
  year={1996},
  volume={1279 2},
  pages={219-26}
}
The pancreatic beta-cell displays an electrical activity consisting of spike bursts and silent phases at glucose concentrations of about 10 mM. The mechanism of initial depolarization induced by glucose is well defined. However, the mechanism inducing the silent phase has not been fully elucidated. In the present study, the possibility of involvement of ATP-sensitive K+ channels in repolarization was examined using the patch-clamp technique in the cell-attached recording configuration. Ouabain… CONTINUE READING