A possible role of sphingosine in induction of apoptosis by tumor necrosis factor-alpha in human neutrophils.

@article{Ohta1994APR,
  title={A possible role of sphingosine in induction of apoptosis by tumor necrosis factor-alpha in human neutrophils.},
  author={Hideki Ohta and Yutaka Yatomi and Elizabeth A. Sweeney and Sen-ichiroh Hakomori and Yasuyuki Igarashi},
  journal={FEBS letters},
  year={1994},
  volume={355 3},
  pages={267-70}
}
Treatment of human neutrophils with tumor necrosis factor-alpha (TNF-alpha) resulted in an increase in concentration of ceramide and its catabolite, sphingosine. Sphingosine, a potent endogenous protein kinase C (PKC) inhibitor, as well as TNF-alpha, induced internucleosomal DNA fragmentation and morphological changes characteristic of apoptotic cells. Ceramide and sphingosine-1-phosphate, the initial product of sphingosine catabolism, did not cause apoptosis under our experimental conditions… CONTINUE READING

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