A possible role of cyclooxygenase‐2 in the relationship between sleep and sudden unexpected death in epilepsy

  title={A possible role of cyclooxygenase‐2 in the relationship between sleep and sudden unexpected death in epilepsy},
  author={Gabriela Matos and Laura Bennedsen and Vanessa Atha{\'i}de Garcia and F{\'u}lvio Alexandre Scorza and Esper Abr{\~a}o Cavalheiro and S{\'e}rgio Tufik and Monica Levy Andersen},
To the Editors: We have read the recent article by Chuang et al. (2012) with great interest. They studied the effects of long-term antiepileptic drug (AED) monotherapy on vascular risk factors and atherosclerosis. They proved that treatment with carbamazepine (CBZ), phenytoin, or valproic acid (VPA) is significantly associated with acceleration of atherosclerosis in patients with epilepsy. Their findings were significantly associated with the duration of AED treatment. Authors concluded that… 



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