A possible role for the loss of CD27-CD70 interaction in myelomagenesis.

  title={A possible role for the loss of CD27-CD70 interaction in myelomagenesis.},
  author={Yuta Katayama and A Tomoyo Sakai and Naohide Oue and Hideki Asaoku and Takemi Otsuki and Takeshi Shiomomura and Rie Masuda and Norihiko Hino and Yasuo Takimoto and Fumio Imanaka and Wataru Yasui and Akiro Kimura},
  journal={British journal of haematology},
  volume={120 2},
CD27 is a marker of memory B cells and its interaction with its ligand, CD70, is very important for differentiation into plasma cells. Although CD27 is detected on normal plasma cells, its expression is significantly reduced with the progression of multiple myeloma (MM), including monoclonal gammopathy of undetermined significance (MGUS). CD27+ myeloma cells are thought to represent an early phase of myeloma, as CD27+ plasma cells from MM patients were found to be composed of normal plasma… CONTINUE READING

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