A possible role for microRNA-141 down-regulation in sunitinib resistant metastatic clear cell renal cell carcinoma through induction of epithelial-to-mesenchymal transition and hypoxia resistance.

@article{Berkers2013APR,
  title={A possible role for microRNA-141 down-regulation in sunitinib resistant metastatic clear cell renal cell carcinoma through induction of epithelial-to-mesenchymal transition and hypoxia resistance.},
  author={Joost Berkers and Olivier Govaere and Pascal Wolter and Benoit Beuselinck and Patrick Sch{\"o}ffski and L{\'e}on C van Kempen and Maarten Albersen and Joost J. van den Oord and Tania A Roskams and Johan Swinnen and Steven Joniau and Hendrik van Poppel and Evelyne Lerut},
  journal={The Journal of urology},
  year={2013},
  volume={189 5},
  pages={1930-8}
}
PURPOSE We identified microRNA driven mechanisms in clear cell renal cell carcinoma associated with the tumor response to the multitargeted receptor tyrosine kinase inhibitor sunitinib. MATERIALS AND METHODS We performed screening genome-wide microRNA real-time quantitative polymerase chain reaction on 20 freshly frozen clear cell renal cell carcinoma tissue samples of patients who received sunitinib as first line targeted therapy. Nine patients with progressive disease within 6 months after… CONTINUE READING
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