A possible role for altered poly(adenosine diphosphoribose)-synthesis in the sensitivity of human head and neck squamous carcinoma cells to ionizing radiation.

@article{Wassermann1988APR,
  title={A possible role for altered poly(adenosine diphosphoribose)-synthesis in the sensitivity of human head and neck squamous carcinoma cells to ionizing radiation.},
  author={Karsten Wassermann and Robert A. Newman and J D McLaughlin and Peter G. Sacks and Leonard A. Zwelling},
  journal={Biochemical and biophysical research communications},
  year={1988},
  volume={154 3},
  pages={1041-6}
}
Cytotoxicity, extent of DNA double-strand breaks, and stimulation of poly(adenosine diphosphoribose)-synthesis were measured in two established human head and neck squamous carcinoma cell lines (183A and 1483) following x-irradiation. The 1483 cell line was 15-fold more resistant to x-ray-mediated cytotoxicity than was the 183A cell line. X-ray-mediated DNA… CONTINUE READING