A possible role for π‐stacking in the self‐assembly of amyloid fibrils

  title={A possible role for $\pi$‐stacking in the self‐assembly of amyloid fibrils},
  author={Ehud Gazit},
  journal={The FASEB Journal},
  pages={77 - 83}
  • E. Gazit
  • Published 1 January 2002
  • Biology, Chemistry
  • The FASEB Journal
Amyloid fibril formation is assumed to be the molecular basis for a variety of diseases of unrelated origin. Despite its fundamental clinical importance, the mechanism of amyloid formation is not fully understood. When we analyzed a variety of short functional fragments from unrelated amyloid‐forming proteins, a remarkable occurrence of aromatic residues was observed. The finding of aromatic residues in diverse fragments raises the possibility that IT‐IT interactions may play a significant role… 

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