A possible pharmacological explanation for quinacrine failure to treat prion diseases: pharmacokinetic investigations in a ovine model of scrapie.

@article{Gayrard2005APP,
  title={A possible pharmacological explanation for quinacrine failure to treat prion diseases: pharmacokinetic investigations in a ovine model of scrapie.},
  author={V{\'e}ronique Gayrard and Nicole Picard-Hagen and Catherine Vigui{\'e} and Valerie M F Laroute and Olivier Andr{\'e}oletti and Pierre-Louis Toutain},
  journal={British journal of pharmacology},
  year={2005},
  volume={144 3},
  pages={
          386-93
        }
}
Quinacrine was reported to have a marked in vitro antiprion action in mouse neuroblastoma cells. On compassionate grounds, quinacrine was administered to Creutzfeldt-Jakob disease patients, despite the absence of preclinical in vivo studies to evaluate efficacy. Quinacrine failed to provide therapeutic benefit. The aim of the study was to investigate possible pharmacokinetic and/or pharmacodynamic explanations for the discrepancy between the proven action of quinacrine in vitro and its lack of… CONTINUE READING
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