A possible mechanism of antidepressant activity of beta-amyrin palmitate isolated from Lobelia inflata leaves in the forced swimming test.

@article{Subarnas1993APM,
  title={A possible mechanism of antidepressant activity of beta-amyrin palmitate isolated from Lobelia inflata leaves in the forced swimming test.},
  author={A Subarnas and Takeshi Tadano and Norimichi Nakahata and Yuichiro Arai and Hiroyasu Kinemuchi and Yoshitake Oshima and Kensuke Kisara and Yasushi Ohizumi},
  journal={Life sciences},
  year={1993},
  volume={52 3},
  pages={
          289-96
        }
}
A mechanism of antidepressant activity of beta-amyrin palmitate was studied using the forced swimming method in mice. Beta-amyrin palmitate (10 mg/kg) reduced the increase in the duration of immobility induced by tetrabenazine (100 and 200 mg/kg), but showed no effect on that in mice treated with alpha-methyl-para-tyrosine (500 mg/kg). Beta-amyrin palmitate… CONTINUE READING