A possible mechanism of a new antispasmodic drug, 2-(1,2-benzisoxazol-3-yl)-3-[2-(2-piperidinoethoxy) phenyl]acrylonitrile (SX-284).

@article{Takayanagi1982APM,
  title={A possible mechanism of a new antispasmodic drug, 2-(1,2-benzisoxazol-3-yl)-3-[2-(2-piperidinoethoxy) phenyl]acrylonitrile (SX-284).},
  author={Issei Takayanagi and Hiroshi Sone and Katsuyoshi Kawashima and Y. Sohji and Toshiaki Kadokawa},
  journal={Japanese journal of pharmacology},
  year={1982},
  volume={32 6},
  pages={
          973-9
        }
}
A newly synthesized drug, SX-284, depressed the twitch response of the ileum from guinea pig to electrical stimulation at 0.1 Hz. SX-284 proved to be almost as active as atropine on electrically stimulated ileum. The responses of guinea pig ileum to nicotine and serotonin were also inhibited by SX-284. However, SX-284 did not influence the release of transmitters from the motor, sympathetic, nonadrenergic inhibitory, noncholinergic excitatory nerves, and responses of various smooth muscles… 
5 Citations

Inhibitory action of 2-(1-,2-benzisoxazol-3-yl)-3-[2-(2-piperidinoethoxy) phenyl]acrylonitrile (SX-284) on acetylcholine release from vagus nerve in guinea pig ileum.

TLDR
Results support the previous findings that SX-284 specifically inhibit acetylcholine release from the vagus nerve in the gastrointestinal canal.

A possible site of action of nicotine in the bronchial smooth muscle preparation of guinea‐pig

TLDR
Contractile response to nicotine was reproducible under the conditions used and nicotine contracted the bronchial smooth muscle concentrationdependently (Fig. 1).

References

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Possible mechanisms of a new type of antispasmodic drug, BTM-1042(cis-(--)-2,3-dihydro-3-(4-methyl-piperazinyl)methyl-2-phenyl-1,5-benzothiazepin-4(5H)-one dihydrochloride).

TLDR
BTM-1042 is apparently a new type of potent, antispasmodic drug that depressed the twitch responses of the ileum from guinea pig to electrical stimulation and blocked muscarinic receptors but the potency was about 1/3 of that of atropine.

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TLDR
Results showed that 5-hydroxytryptamine activates specific receptors sited at the intramural parasympathetic ganglion cells and mediated its response through the nervous plexus, similar to nicotine, choline phenyl ether and dimethylphenylpiperazinium.

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TLDR
The results are consistent with the hypothesis that non‐cholinergic excitatory nerves to the guinea‐pig bladder release a purine nucleotide, but do not provide critical evidence for it.

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The movements of a strip of fundus from a rat stomach, suspended in a 5 ml. bath at 37°, are recorded by a spring‐loaded lever. The muscle is stretched for 15 to 30 sec. between contractions. 1 ng.

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    British journal of pharmacology and chemotherapy
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TLDR
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TLDR
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