A possible mechanism for the peroxidation of lipids due to chronic ethanol ingestion.

@article{Reitz1975APM,
  title={A possible mechanism for the peroxidation of lipids due to chronic ethanol ingestion.},
  author={Ronald C. Reitz},
  journal={Biochimica et biophysica acta},
  year={1975},
  volume={380 2},
  pages={145-54}
}
The effects of chronic ethanol ingestion on NADPH-oxidase and on the NADPH-catalyzed peroxidation of lipids in rat liver microsomes have been studied. It was demonstrated that the rates of NADPH oxidation, of oxygen consumption, and of malondialdehyde formation increased significantly above control values after one month of ethanol ingestion. Further, the fatty acid composition of these microsomes revealed a decrease in arachidonate and in the C22 polyenes. Also, the energies of activation for… CONTINUE READING