A possible mechanism for the occurrence of the non-specific potentiation in the denervated skeletal muscle of the rat.

Denervation itself produces a striking alteration in the surface membrane of muscle fiber in which the region of acetvicholine sensitivity spreads out from the endplates to the whole of the fiber membrane in the rat (1, 2) and in the frog (3). In addition, changes in the characteristics of the sarcoplasmic reticulum may be considered as a possible mechanism… CONTINUE READING