A possible mechanism for inhibition of angiogenesis by angiostatic steroids: induction of capillary basement membrane dissolution.

@article{Ingber1986APM,
  title={A possible mechanism for inhibition of angiogenesis by angiostatic steroids: induction of capillary basement membrane dissolution.},
  author={Donald E. Ingber and Joseph A. Madri and Judah M Folkman},
  journal={Endocrinology},
  year={1986},
  volume={119 4},
  pages={1768-75}
}
A new class of angiostatic steroids acts independently of previously identified steroid functions to inhibit angiogenesis when administered with heparin. Development of angiostatic steroids as therapeutic modulators of blood vessel growth would be greatly facilitated if their mode of action were thoroughly understood. However, the mechanism by which these steroids produce capillary regression is not known. The distributions of fibronectin and laminin were studied in growing and regressing… CONTINUE READING