A possible link between skeletal muscle mitochondrial efficiency and age-induced insulin resistance.

@article{Iossa2004APL,
  title={A possible link between skeletal muscle mitochondrial efficiency and age-induced insulin resistance.},
  author={Susanna Iossa and Maria Pina Mollica and Lill{\`a} Lionetti and Raffaella Crescenzo and Rosaria Tasso and Giovanna Liverini},
  journal={Diabetes},
  year={2004},
  volume={53 11},
  pages={2861-6}
}
The transition from young to adult age is associated with decreased insulin sensitivity. To investigate whether changes in skeletal muscle mitochondrial function could be involved in the development of insulin resistance, we measured the oxidative capacity and energetic efficiency of subsarcolemmal and intermyofibrillar mitochondria isolated from the skeletal muscle of 60- and 180-day-old rats. Mitochondrial efficiency was tested by measuring the degree of thermodynamic coupling and optimal… CONTINUE READING
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