A possible key role of vision in the development of schizophrenia

@article{Csszr2019APK,
  title={A possible key role of vision in the development of schizophrenia},
  author={No{\'e}mi Cs{\'a}sz{\'a}r and G{\'a}bor Kap{\'o}cs and Istv{\'a}n B{\'o}kkon},
  journal={Reviews in the Neurosciences},
  year={2019},
  volume={30},
  pages={359 - 379}
}
Abstract Based on a brief overview of the various aspects of schizophrenia reported by numerous studies, here we hypothesize that schizophrenia may originate (and in part be performed) from visual areas. In other words, it seems that a normal visual system or at least an evanescent visual perception may be an essential prerequisite for the development of schizophrenia as well as of various types of hallucinations. Our study focuses on auditory and visual hallucinations, as they are the most… 
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References

SHOWING 1-10 OF 288 REFERENCES
Schizophrenia and the eye
Towards a Neuropsychology of Schizophrenia
TLDR
It is proposed that the negative signs of schizophrenia reflect a defects in the initiation of spontaneous action, while the positive symptoms reflect a defect in the internal monitoring of action.
Visual Perception and Its Impairment in Schizophrenia
Schizophrenia and cortical blindness: protective effects and implications for language
TLDR
It is argued that a distinction between different types of blindness in terms of the origin of the visual deficit, cortical or peripheral, is crucial for understanding the observed patterns of comorbidity.
Vision, language and a protective mechanism towards psychosis
High prevalence of visual hallucinations in research subjects with chronic schizophrenia.
TLDR
The fact that in 43% of the patients with visual hallucinations the history of visual hallucinations was first documented during the research ward work-up suggests that clinicians frequently do not inquire about visual hallucinations in patients with chronic schizophrenia.
Early-stage visual processing deficits in schizophrenia
TLDR
Understanding the nature of sensory processing deficits may provide insight into mechanisms of pathology in schizophrenia, such as N-methyl-D-aspartate dysfunction or impaired signal amplification, and could lead to treatment strategies including sensory processing rehabilitation that may improve outcome.
Cognitive Identity in Schizophrenia: Vision, Space, and Body Perception from Prodrome to Syndrome
TLDR
It is demonstrated that cognitive aberrations associated with impairments of the visual system are disease progression markers from the early SZ prodrome to the chronic, stabilized syndrome, and provides evidence that etiological explanations of schizophrenia need to take into account anomalous visual information acquisition and processing as dimensional stage markers of the disease.
Perceptual changes in schizophrenia: a questionnaire survey
TLDR
The results are discussed with reference to the hypothesis that perceptual malfunction may underlie some other schizophrenic disorders such as delusions or catatonia.
The neural basis of Charles Bonnet hallucinations: a hypothesis
  • W. Burke
  • Medicine
    Journal of neurology, neurosurgery, and psychiatry
  • 2002
TLDR
It is proposed that the hallucinations result from activation of the ‘blobs’ of area V1 and the “stripes” of areas V2 in the visual cortex and a theory is proposed to account for the disappearance of the hallucinations by a “filling in” mechanism.
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