A possible interaction between systemic and renal angiotensinogen in the control of blood pressure.

Abstract

BACKGROUND Angiotensinogen (AGT) is synthesized in the liver and proximal tubule. AGT overexpression at either site might increase blood pressure (BP). We used transgenic mice with AGT overexpression in proximal tubule (K), liver (L), or both sites (KL) to determine the relative contributions of hepatic- and proximal tubule-derived AGT in modulating BP… (More)
DOI: 10.1093/ajh/hps078

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