A possible extended family of regulators of sigma factor activity in Streptomyces coelicolor.

@article{Kim2008APE,
  title={A possible extended family of regulators of sigma factor activity in Streptomyces coelicolor.},
  author={Eun Sook Kim and Ju Yeon Song and Dae Wi Kim and Keith F. Chater and Kye Joon Lee},
  journal={Journal of bacteriology},
  year={2008},
  volume={190 22},
  pages={7559-66}
}
SCO4677 is one of a large number of similar genes in Streptomyces coelicolor that encode proteins with an HATPase_c domain resembling that of anti-sigma factors such as SpoIIAB of Bacillus subtilis. However, SCO4677 is not located close to genes likely to encode a cognate sigma or anti-anti-sigma factor. SCO4677 was found to regulate antibiotic production and morphological differentiation, both of which were significantly enhanced by the deletion of SCO4677. Through protein-protein interaction… CONTINUE READING

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