A possible explanation for a neurotoxic effect of the anticancer agent oxaliplatin on neuronal voltage-gated sodium channels.

@article{Grolleau2001APE,
  title={A possible explanation for a neurotoxic effect of the anticancer agent oxaliplatin on neuronal voltage-gated sodium channels.},
  author={Françoise Grolleau and Laurence Gamelin and Mich{\'e}le Boisdron-Celle and Bruno Lapied and Marcel Pelhate and Erick Gamelin},
  journal={Journal of neurophysiology},
  year={2001},
  volume={85 5},
  pages={
          2293-7
        }
}
Oxaliplatin, a new widely used anticancer drug, displays frequent, sometimes severe, acute sensory neurotoxicity accompanied by neuromuscular signs that look like the symptoms observed in tetany and myotonia. The whole cell patch-clamp technique was employed to investigate the oxaliplatin effects on the electrophysiological properties of short-term cultured dorsal unpaired median (DUM) neurons isolated from the CNS of the cockroach Periplaneta americana. Within the clinical concentration range… CONTINUE READING
Highly Cited
This paper has 145 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 84 extracted citations

Chemotherapy-induced peripheral neuropathy: a review and implications for oncology nursing practice.

Clinical journal of oncology nursing • 2007
View 5 Excerpts
Highly Influenced

145 Citations

01020'02'05'09'13'17
Citations per Year
Semantic Scholar estimates that this publication has 145 citations based on the available data.

See our FAQ for additional information.

References

Publications referenced by this paper.
Showing 1-10 of 24 references

LORTHOLARY A, AND LARRA F. Long term pharmacokinetic behaviour platinum after cisplatin administration

E GAMELIN, P ALLAIN, P MAILLART, A TURCANT, R DELVA
Cancer Chemother Pharmacol • 1998

Oxaliplatin: a review of preclinical and clinical studies.

Annals of oncology : official journal of the European Society for Medical Oncology • 1998