A possible correlation between drug-induced hallucinations in man and a behavioural response in mice

@article{Corne2004APC,
  title={A possible correlation between drug-induced hallucinations in man and a behavioural response in mice},
  author={S. J. Corne and Raymond W. Pickering},
  journal={Psychopharmacologia},
  year={2004},
  volume={11},
  pages={65-78}
}
SummaryThe production of head-twitches in mice appears to be a suitable laboratory test for predicting whether a compound is likely to be hallucinogenic in man. This is based on the following findings:1.With the exception of acetyl-lysergic acid diethylamide and nalorphine, hallucinogenic drugs induced head-twitches in mice.2.Chemically related compounds which are not hallucinogenic did not induce head-twitches with the exception of 5-HTP, ergometrine, α-ethylmescaline and DMPE. It is suggested… 
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TLDR
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TLDR
Hallucinogen-induced stimulus control provides a unique behavioral tool for the prediction of subjective effects in man and for the elucidation of the pharmacological mechanisms of the action of these agents.
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TLDR
It is confirmed that psilocin acts as an agonist at 5-HT1A, 4-hydroxy-N,N-dimethyltryptamine, and 5- HT2C receptors in mice, whereas the behavioral effects of 1-methylpsilocin indicate that this compound is acting at5-HT2A sites but is inactive at the 5-ht1A receptor.
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