A possible common mechanism of action of antidepressant treatments

@article{Vetulani1976APC,
  title={A possible common mechanism of action of antidepressant treatments},
  author={Jerzy Vetulani and Robert J. Stawarz and James V. Dingell and Fridolin Sulser},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={1976},
  volume={293},
  pages={109-114}
}
The response of the norepinephrine (NE) sensitive cyclic AMP generating system in slices of the rat limbic forebrain after both the acute and chronic administration of the tricyclic antidepressants desipramine (DMI) and iprindole as well as electroconvulsive treatment (ECT) was investigated. Neither the basal level of cyclic AMP nor the hormonal response to NE were altered after the administration of a single dose or short term treatment with DMI and iprindole. However, the administration of… CONTINUE READING