A possible central antinociceptive effect of dipyrone in mice.

@article{Akman1996APC,
  title={A possible central antinociceptive effect of dipyrone in mice.},
  author={Hasan O. Akman and Fazilet Aksu and Isil G{\"u}ltekin and Hanefi Ozbek and Uğur Oral and F. S. A. Doran and Firuz Baysal},
  journal={Pharmacology},
  year={1996},
  volume={53 2},
  pages={
          71-8
        }
}
The antinociceptive effect of dipyrone, a nonsteroidal and inflammatory drug, was studied in a series of experiment employing tail-flick and hot-place models and the abdominal constrictor test. The drug was given via intracerebroventricular (i.c.v.), intrathecal (i.t.) or subcutaneous (s.c.) routes. Dipyrone exhibited no analgesic activity in the tail-flick and hotplate tests while it inhibited the number of stretches in a dose-dependent manner. The antinociceptive effect of dipyrone… CONTINUE READING

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