A positron emission tomography study of quetiapine in schizophrenia: a preliminary finding of an antipsychotic effect with only transiently high dopamine D2 receptor occupancy.

@article{Kapur2000APE,
  title={A positron emission tomography study of quetiapine in schizophrenia: a preliminary finding of an antipsychotic effect with only transiently high dopamine D2 receptor occupancy.},
  author={Sandeep Kapur and Robert B Zipursky and Chris Jones and Chekkera Shammi and Gary J. Remington and Philip Seeman},
  journal={Archives of general psychiatry},
  year={2000},
  volume={57 6},
  pages={553-9}
}
BACKGROUND Quetiapine is a new atypical antipsychotic medication. As such, relatively little has been published regarding its in vivo effects at the dopamine type 2 (D2) and serotonin type 2a (5-HT2a) receptor systems. The following study was undertaken to explore these effects across the clinical dose range and relate this information to its clinical profile. METHODS Twelve patients with schizophrenia were randomly assigned to doses of 150 to 600 mg/d (n=3, at 150, 300, 450, and 600 mg/d) of… CONTINUE READING
Highly Influential
This paper has highly influenced 12 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 135 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 42 references

Management decisions on priority pipeline products-MDL 100907 [press release

  • S. Report
  • Vision Extra,
  • 1999

Receptor occupancy by antipsychotics: concepts and findings

  • S. Kapur
  • Lidow M, ed. Role of Neurotransmitter Receptors…
  • 1999

Similar Papers

Loading similar papers…