A positive role for PERIOD in mammalian circadian gene expression.

Abstract

In the current model of the mammalian circadian clock, PERIOD (PER) represses the activity of the circadian transcription factors BMAL1 and CLOCK, either independently or together with CRYPTOCHROME (CRY). Here, we provide evidence that PER has an entirely different function from that reported previously, namely, that PER inhibits CRY-mediated… (More)
DOI: 10.1016/j.celrep.2014.03.072

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