A positive feedback mechanism governs the polarity and motion of motile cilia

@article{Mitchell2007APF,
  title={A positive feedback mechanism governs the polarity and motion of motile cilia},
  author={B. Mitchell and R. Jacobs and J. Li and S. Chien and C. Kintner},
  journal={Nature},
  year={2007},
  volume={447},
  pages={97-101}
}
Ciliated epithelia produce fluid flow in many organ systems, ranging from the respiratory tract where it clears mucus to the ventricles of the brain where it transports cerebrospinal fluid. Human diseases that disable ciliary flow, such as primary ciliary dyskinesia, can compromise organ function or the ability to resist pathogens, resulting in recurring respiratory infections, otitis, hydrocephaly and infertility. To create a ciliary flow, the cilia within each cell need to be polarized… Expand
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