A positive feedback loop between hepatocyte growth factor receptor and β-catenin sustains colorectal cancer cell invasive growth

@article{Rasola2007APF,
  title={A positive feedback loop between hepatocyte growth factor receptor and β-catenin sustains colorectal cancer cell invasive growth},
  author={Andrea Rasola and Michela Fassetta and F De Bacco and Lorenza Alice D'Alessandro and Daniela Gramaglia and Maria Flavia Di Renzo and Paolo Maria Comoglio},
  journal={Oncogene},
  year={2007},
  volume={26},
  pages={1078-1087}
}
Overexpressed or activated hepatocyte growth factor receptor, encoded by the MET proto-oncogene, was found in the majority of colorectal carcinomas (CRCs), whose stepwise progression to malignancy requires transcriptional activation of β-catenin. We here demonstrate that a functional crosstalk between Met and β-catenin signaling sustains and increases CRC cell invasive properties. Hepatocyte growth factor (HGF) stimulation prompts β-catenin tyrosine phosphorylation and dissociation from Met… CONTINUE READING

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