A positive feedback loop between Dumbfounded and Rolling pebbles leads to myotube enlargement in Drosophila

@article{Menon2005APF,
  title={A positive feedback loop between Dumbfounded and Rolling pebbles leads to myotube enlargement in Drosophila},
  author={Sree Devi Menon and Zalina B Osman and Kho Chenchill and William N. Chia},
  journal={The Journal of Cell Biology},
  year={2005},
  volume={169},
  pages={909 - 920}
}
In Drosophila, myoblasts are subdivided into founders and fusion-competent myoblasts (fcm) with myotubes forming through fusion of one founder and several fcm. Duf and rolling pebbles 7 (Rols7; also known as antisocial) are expressed in founders, whereas sticks and stones (SNS) is present in fcm. Duf attracts fcm toward founders and also causes translocation of Rols7 from the cytoplasm to the fusion site. We show that Duf is a type 1 transmembrane protein that induces Rols7 translocation… CONTINUE READING

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