A positive feedback cell signaling nucleation model of astrocyte dynamics

@inproceedings{MacDonald2013APF,
  title={A positive feedback cell signaling nucleation model of astrocyte dynamics},
  author={Christopher L. MacDonald and Gabriel A. Silva},
  booktitle={Front. Neuroeng.},
  year={2013}
}
We constructed a model of calcium signaling in astrocyte neural glial cells that incorporates a positive feedback nucleation mechanism, whereby small microdomain increases in local calcium can stochastically produce global cellular and intercellular network scale dynamics. The model is able to simultaneously capture dynamic spatial and temporal heterogeneities associated with intracellular calcium transients in individual cells and intercellular calcium waves (ICW) in spatially realistic… CONTINUE READING

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We constructed a model of calcium signaling in astrocyte neural glial cells that incorporates a positive feedback nucleation mechanism , whereby small microdomain increases in local calcium can stochastically produce global cellular and intercellular network scale dynamics .
We constructed a model of calcium signaling in astrocyte neural glial cells that incorporates a positive feedback nucleation mechanism , whereby small microdomain increases in local calcium can stochastically produce global cellular and intercellular network scale dynamics .
We constructed a model of calcium signaling in astrocyte neural glial cells that incorporates a positive feedback nucleation mechanism , whereby small microdomain increases in local calcium can stochastically produce global cellular and intercellular network scale dynamics .
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