A positive cooperativity binding model between Ly49 natural killer cell receptors and the viral immunoevasin m157: kinetic and thermodynamic studies.

@article{Romasanta2014APC,
  title={A positive cooperativity binding model between Ly49 natural killer cell receptors and the viral immunoevasin m157: kinetic and thermodynamic studies.},
  author={Pablo Nicol{\'a}s Romasanta and Lucrecia Mar{\'i}a Curto and Nicol{\'a}s Urtasun and Mar{\'i}a B Sarratea and Santiago Chiappini and Mar{\'i}a Victoria Miranda and Jos{\'e} Mar{\'i}a Delfino and Roy A. Mariuzza and M. Marcello Fern{\'a}ndez and Emilio L Malchiodi},
  journal={The Journal of biological chemistry},
  year={2014},
  volume={289 8},
  pages={5083-96}
}
Natural killer (NK) cells discriminate between healthy and virally infected or transformed cells using diverse surface receptors that are both activating and inhibitory. Among them, the homodimeric Ly49 NK receptors, which can adopt two distinct conformations (backfolded and extended), are of particular importance for detecting cells infected with mouse cytomegalovirus (CMV) via recognition of the viral immunoevasin m157. The interaction of m157 with activating (Ly49H) and inhibitory (Ly49I… CONTINUE READING
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