A porphyrin increases survival time of mice after intracerebral prion infection.

@article{Kocisko2006API,
  title={A porphyrin increases survival time of mice after intracerebral prion infection.},
  author={David A. Kocisko and Winslow S. Caughey and Richard E. Race and Grant Y Roper and Byron Caughey and John Douglas Morrey},
  journal={Antimicrobial agents and chemotherapy},
  year={2006},
  volume={50 2},
  pages={
          759-61
        }
}
Prion diseases, including scrapie, are incurable neurodegenerative disorders. Some compounds can delay disease after a peripheral scrapie inoculation, but few are effective against advanced disease. Here, we tested multiple related porphyrins, but only Fe(III)meso-tetra(4-sulfonatophenyl)porphine injected into mouse brains after intracerebral scrapie inoculation substantially increased survival times. 

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Cell models of prion infection.

  • Veterinary research
  • 2008
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