A porous silicon-based optical interferometric biosensor.

@article{Lin1997APS,
  title={A porous silicon-based optical interferometric biosensor.},
  author={Victor S.-Y. Lin and K Motesharei and K P Dancil and Michael J Sailor and Mohammad Reza Ghadiri},
  journal={Science},
  year={1997},
  volume={278 5339},
  pages={840-3}
}
A biosensor has been developed based on induced wavelength shifts in the Fabry-Perot fringes in the visible-light reflection spectrum of appropriately derivatized thin films of porous silicon semiconductors. Binding of molecules induced changes in the refractive index of the porous silicon. The validity and sensitivity of the system are demonstrated for small organic molecules (biotin and digoxigenin), 16-nucleotide DNA oligomers, and proteins (streptavidin and antibodies) at pico- and… CONTINUE READING

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