A porcine model of osteosarcoma

  title={A porcine model of osteosarcoma},
  author={Anja Saalfrank and K-P Janssen and Morgane Ravon and Krzysztof Flisikowski and Stefan Eser and Katja Steiger and Tatiana Flisikowska and P M{\"u}ller-Fliedner and {\'E} Schulze and C Br{\"o}nner and Alexandra Gnann and Eva Kappe and Britta B{\"o}hm and B Schade and Ulrich Certa and Dieter Saur and Ir{\'e}ne Esposito and Alexander J. Kind and Angelika Schnieke},
We previously produced pigs with a latent oncogenic TP53 mutation. Humans with TP53 germline mutations are predisposed to a wide spectrum of early-onset cancers, predominantly breast, brain, adrenal gland cancer, soft tissue sarcomas and osteosarcomas. Loss of p53 function has been observed in >50% of human cancers. Here we demonstrate that porcine mesenchymal stem cells (MSCs) convert to a transformed phenotype after activation of latent oncogenic TP53R167H and KRASG12D, and overexpression of… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 3 times over the past 90 days. VIEW TWEETS
8 Extracted Citations
63 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.

Similar Papers

Loading similar papers…