A population-level decline in serum testosterone levels in American men.

@article{Travison2007APD,
  title={A population-level decline in serum testosterone levels in American men.},
  author={Thomas G. Travison and Andre B. Araujo and Amy B O'donnell and Varant Kupelian and John B. Mckinlay},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2007},
  volume={92 1},
  pages={
          196-202
        }
}
CONTEXT Age-specific estimates of mean testosterone (T) concentrations appear to vary by year of observation and by birth cohort, and estimates of longitudinal declines in T typically outstrip cross-sectional decreases. [] Key MethodDESIGN We describe a prospective cohort study of health and endocrine functioning in randomly selected men of age 45-79 yr. We provide three data collection waves: baseline (T1: 1987-1999) and two follow-ups (T2: 1995-1997, T3: 2002-2004).
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274 Citations
Highly Influential Citations
4
Background Citations
78
Methods Citations
3
Results Citations
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274 Citations

Citation Type

Citation Type

The relative contributions of aging, health, and lifestyle factors to serum testosterone decline in men.
TLDR
Both chronological aging and changes in health and lifestyle factors are associated with declines in serum T, and the possibility that age-related hormone decline may be decelerated through the management of health andifestyle factors is suggested.
A cohort effect on serum testosterone levels in Finnish men.
TLDR
The more recently born Finnish men have lower testosterone levels than their earlier born peers, suggesting that while there may be detrimental changes at the gonad level, the hypothalamus-pituitary-axis is not responding appropriately to this change.
Longitudinal changes in testosterone over five years in community-dwelling men.
TLDR
An age-related decline in T levels is not inevitable but is largely explained by smoking behavior and intercurrent changes in health status, particularly obesity and depression.
Individual testosterone decline and future mortality risk in men.
TLDR
Higher mortality rates were seen among the men who had the most pronounced age-related decline in TS, independent of their baseline TS levels, as well as in cause-specific mortality analyses.
Age-related changes in serum testosterone and sex hormone binding globulin in Australian men: longitudinal analyses of two geographically separate regional cohorts.
TLDR
Age-related changes in blood testosterone and SHBG previously described in urban-dwelling men are the same in men who reside in smaller regional cities of another continent.
Temporal trends in testosterone levels and treatment in older men
TLDR
Existing evidence, though limited, supports the hypothesis of secular declines in serum testosterone levels in adult men, and it is conceivable that these trends may influence the health of the public.
Early decline of androgen levels in healthy adult men: an effect of aging per se? A prospective cohort study.
TLDR
Serum androgen levels start declining early during adult life and independently from changes in BMI and other lifestyle factors, suggesting that aging per se leads to an altered sex steroid status.
Secular decline in male testosterone and sex hormone binding globulin serum levels in Danish population surveys.
TLDR
The observed age-independent changes in SHBG and testosterone may be explained by an initial change in SH BG levels, which subsequently lead to adjustment of testosterone at a lower level to sustain free testosterone levels.
Decline in Serum Testosterone Levels Among Adolescent and Young Adult Men in the USA.
Bioavailable Testosterone Linearly Declines Over A Wide Age Spectrum in Men and Women From The Baltimore Longitudinal Study of Aging.
  • E. Fabbri, Y. An, +6 authors L. Ferrucci
  • Medicine
    The journals of gerontology. Series A, Biological sciences and medical sciences
  • 2016
TLDR
In both men and women, mBT linearly declines over the life span and even at old ages, and its relationship with age-related phenotypes should be further investigated.
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