A population genetics perspective on the determinants of intra-tumor heterogeneity.

@article{Hu2017APG,
  title={A population genetics perspective on the determinants of intra-tumor heterogeneity.},
  author={Zheng Wen Hu and Ruping Sun and Christina Curtis},
  journal={Biochimica et biophysica acta. Reviews on cancer},
  year={2017},
  volume={1867 2},
  pages={
          109-126
        }
}
Cancer results from the acquisition of somatic alterations in a microevolutionary process that typically occurs over many years, much of which is occult. Understanding the evolutionary dynamics that are operative at different stages of progression in individual tumors might inform the earlier detection, diagnosis, and treatment of cancer. Although these processes cannot be directly observed, the resultant spatiotemporal patterns of genetic variation amongst tumor cells encode their evolutionary… CONTINUE READING
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