A population-based study of BRCA1 and BRCA2 mutations in Jewish women with epithelial ovarian cancer.

@article{Lu1999APS,
  title={A population-based study of BRCA1 and BRCA2 mutations in Jewish women with epithelial ovarian cancer.},
  author={Karen H. Lu and Daniel W Cramer and Michael G. Muto and Emmy Yuen-mei Li and Jonathan Niloff and S. C. Mok},
  journal={Obstetrics and gynecology},
  year={1999},
  volume={93 1},
  pages={34-7}
}
OBJECTIVE To determine the frequency of BRCA1 mutations 185delAG and 5382insC and BRCA2 mutation 6174delT in Jewish women with ovarian cancer and in matched controls in a population-based study. METHODS Forty-eight Jewish women with epithelial ovarian cancer (32 invasive and 16 borderline) and 33 Jewish control subjects were obtained from a population-based, case-control study of ovarian cancer in eastern Massachusetts and New Hampshire. Mutational analysis on exons 2 and 20 of BRCA1 and exon… CONTINUE READING

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