A population-based latent variable approach for association mapping of quantitative trait loci.

@article{Wang2006APL,
  title={A population-based latent variable approach for association mapping of quantitative trait loci.},
  author={Tao Wang and Bruce Weir and Zhao-Bang Zeng},
  journal={Annals of human genetics},
  year={2006},
  volume={70 Pt 4},
  pages={506-23}
}
A population-based latent variable approach is proposed for association mapping of quantitative trait loci (QTL), using multiple closely linked genetic markers within a small candidate region in the genome. By incorporating QTL as latent variables into a penetrance model, the QTL are flexible to characterize either alleles at putative trait loci or… CONTINUE READING